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Helena Ljusberg Wahren

Helena Ljusberg-Wahren

Innovation developer

Helena Ljusberg Wahren

Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate

Author

  • Dan Lundberg
  • Géraldine Lafitte
  • Helena Ljusberg
  • Pernilla Lennernaes
  • Krister Thuresson

Summary, in English

The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.

Department/s

  • Physical Chemistry
  • LU Innovation

Publishing year

2009

Language

English

Pages

920-928

Publication/Series

Journal of Dispersion Science and Technology

Volume

30

Issue

6

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Physical Chemistry

Keywords

  • self-emulsifying drug-delivery system
  • mucin
  • microemulsion
  • Bioavailability
  • cationic amphiphile

Status

Published

ISBN/ISSN/Other

  • ISSN: 0193-2691